Angiogenesis is a physiological process involving the growth of new blood vessels from pre-existing vessels. Though there has been some debate over this, vasculogenesis is the term used for spontaneous blood-vessel formation, and intussusception is the term for new blood vessel formation by splitting off existing ones.Angiogenesis is a normal process in growth and development, as well as in wound healing. However, this is also a fundamental step in the transition of tumors from a dormant state to a malignant state.
Intelligent Design? A scientist begins by asking a question that can be answered by gathering evidence. Questions arise in all sorts of ways: for example, from observations, unexpected results, or the research findings of others. The scientist then develops an initial hypothesis, or possible answer to the question, arrived at based on past research or experience. In exploring the complex biology that enables cancerous tumors to grow, Dr. Judah Folkman formed his initial hypothesis based on decades of research. He suggested that tumors themselves can induce the formation of blood vessels, which in turn nourish the tumors. This phenomenon is called angiogenesis.
Dr. Moses Judah Folkman (February 24, 1933 - 14 January 2008) was an American medical scientist best known for his research on angiogenesis and vasculogenesis, processes where tumors generate tiny blood vessels to nourish themselves. His work founded a branch of cancer research called 'anti-angiogenesis therapy'.
Born in 1933 in Cleveland, Ohio, Judah Folkman accompanied his father, a rabbi, on visits to hospital patients. By age seven, he knew he wanted to be a doctor, rather than follow in his father's footsteps, so he could offer cures in addition to comfort. His father replied, "In that case, you can be a rabbi-like doctor," words his son took to heart.  Dr. Folkman graduated Ohio State University in 1953, and then Harvard Medical School in 1957. While still a student at Harvard Medical School, he developed one of the first pacemakers. After his graduation, he did his surgical residency at Massachusetts General Hospital, where he rose to the rank of chief resident in surgery. During this time, Folkman worked on liver cancer and atrio-pacemakers.Between 1960 and 1962, Folkman served in the United States Navy, as a Lieutenant, where he studied blood vessel growth. He worked at the National Naval Medical Center in Bethesda, Maryland. During his service in the U.S. Navy, Folkman created an implantable device for timed drug-release, and donated it patent-free to the World Population Council. It is now known as Norplant.